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Invitrogen
SAP30L Polyclonal Antibody
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Product Details
PA5-140017
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human SAP30L. Recombinant protein control fragment (Product #RP-109670).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.
Immunogen sequence: MNGFSTEEDS REGPPAAPAA AAPGYGQSCC LIE
Highest antigen sequence indentity to the following orthologs: Rat - 94%, Mouse - 94%.
Target Information
A novel TGF- beta up-regulated mRNA species, the Sin3-associated protein 30-like, SAP30L has been identified. The predicted nuclear localization signal of SAP30L is sufficient for nuclear transport of the protein although mutating it does not completely remove SAP30L from the nuclei. By reason of its nuclear localization and close homology to SAP30 it is thought that SAP30L might have a role in recruiting the Sin3-histone deacetylase complex to specific co-repressor complexes in response to TGF-beta, leading to the silencing of proliferation-driving genes in the differentiating intestinal epithelial cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp667L2214; FLJ11526; FLJ23595; FLJ36497; HCV non-structural protein 4A-transactivated protein 2; Histone deacetylase complex subunit SAP30L; SAP30L; Sin3 corepressor complex subunit SAP30L; Sin3-associated protein p30-like; Sin3A associated protein p30-like; transactivated by nonstructural protein 4A of hepatitis C virus; unnamed protein product
Gene Aliases: NS4ATP2; SAP30L
UniProt ID: (Human) Q9HAJ7
Entrez Gene ID: (Human) 79685
DNA binding
transcription cofactor activity
protein binding
zinc ion binding
lipid binding
phosphatidylinositol-5-phosphate binding
nucleosome binding
phosphatidylinositol-3-phosphate binding
histone binding
non-sequence-specific DNA binding, bending
metal ion binding
phosphatidylinositol-4-phosphate binding
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
negative regulation of cell migration
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of stem cell population maintenance
positive regulation of stem cell population maintenance
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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