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Invitrogen
EPC1 Polyclonal Antibody
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Product Details
PA5-140053
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human EPC1. Recombinant protein control fragment (Product #RP-108787).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.
Immunogen sequence: DYDSVFHHLD LEMLSSPQHS PVNQFANTSE TNTSDKSFSK DLSQILVNIK SCRWRHFRPR TPSLHDSDND ELSCRKLYRS INRTGTAQPG TQTCSTSTQS KSSSGSAHFA FTAEQYQQHQ QQLALMQKQQ LAQIQQQQA
Highest antigen sequence indentity to the following orthologs: Mouse - 83%, Rat - 83%.
Target Information
EPC1 is a component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp781P2312; Enhancer of polycomb homolog 1; Epl 1; polycomb-group protein; EPC; unnamed protein product
Gene Aliases: EPC1; Epl1
UniProt ID: (Human) Q9H2F5
Entrez Gene ID: (Human) 80314
negative regulation of transcription from RNA polymerase II promoter
double-strand break repair via homologous recombination
double-strand break repair via nonhomologous end joining
chromatin organization
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
spermatogenesis
spermatid development
cell differentiation
sperm chromatin condensation
regulation of apoptotic process
negative regulation of gene expression, epigenetic
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of cell cycle
positive regulation of double-strand break repair via homologous recombination
regulation of double-strand break repair
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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