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Invitrogen
Dematin Polyclonal Antibody
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Product Details
PA5-140094
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human DMTN. Recombinant protein control fragment (Product #RP-108960).
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.
Immunogen sequence: DDDSGEEMKA LRERQREELS KVTSNLGKMI LKEEMEKSLP IRRKTRSLPD RTPFHTSLHQ GT
Highest antigen sequence indentity to the following orthologs: Rat - 92%, Mouse - 92%.
Target Information
The protein encoded by this gene is an actin binding and bundling protein that plays a structural role in erythrocytes, by stabilizing and attaching the spectrin/actin cytoskeleton to the erythrocyte membrane in a phosphorylation-dependent manner. This protein contains a core domain in the N-terminus, and a headpiece domain in the C-terminus that binds F-actin. When purified from erythrocytes, this protein exists as a trimer composed of two 48 kDa polypeptides and a 52 kDa polypeptide. The different subunits arise from alternative splicing in the 3' coding region, where the headpiece domain is located. Disruption of this gene has been correlated with the autosomal dominant Marie Unna hereditary hypotrichosis disease, while loss of heterozygosity of this gene is thought to play a role in prostate cancer progression. Alternative splicing results in multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Dematin; Dematin actin-binding protein; Erythrocyte membrane protein band 4.9; erythrocyte membrane protein band 4.9 (dematin); unnamed protein product
Gene Aliases: DMT; DMTN; EPB49
UniProt ID: (Human) Q08495
Entrez Gene ID: (Human) 2039
cytoskeleton organization
regulation of cell shape
regulation of lamellipodium assembly
positive regulation of fibroblast migration
negative regulation of peptidyl-threonine phosphorylation
negative regulation of cell-substrate adhesion
lamellipodium assembly
actin cytoskeleton organization
regulation of actin cytoskeleton organization
negative regulation of peptidyl-serine phosphorylation
erythrocyte development
negative regulation of peptidyl-tyrosine phosphorylation
actin filament bundle assembly
regulation of filopodium assembly
smooth endoplasmic reticulum calcium ion homeostasis
actin filament capping
negative regulation of focal adhesion assembly
protein-containing complex assembly
cellular response to cAMP
endoplasmic reticulum tubular network organization
positive regulation of wound healing
negative regulation of protein targeting to membrane
negative regulation of substrate adhesion-dependent cell spreading
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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