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Invitrogen
ZMIZ1 Polyclonal Antibody
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Product Details
PA5-140136
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human ZMIZ1. Recombinant protein control fragment (Product #RP-109251).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.
Immunogen sequence: EPNYGNQQYG PNSQFPTQPG QYPAPNPPRP LTSPNYPGQR MPSQPSSGQY PPPTVNMGQY YKPEQFNGQN NTFSGSSYSN YSQGNV
Highest antigen sequence indentity to the following orthologs: Rat - 94%, Mouse - 94%.
Target Information
Retinoic acid plays a critical role in development, cellular growth, and differentiation and induces the expression of a variety of genes. RAI17 expression is induced by retinoic acid and is predominantly expressed in heart, brain and ovaries. Within brain, highest expression is in amygdala. The deduced 1,067-amino acid protein contains an MSX-interacting zinc finger (MIZ) domain, a nuclear localization signal sequence, and 2 proline-rich regions. A strong intrinsic transactivation domain is identified in the C-terminal proline-rich region. RAI17 expression is detected in various cancer cell lines. RAI17 colocalizes with endogenous androgen receptor (AR) in the nuclei of prostate epithelial cells from human tissue samples. In human prostate cancer cells, RAI17 increases the transcriptional activity of AR. Studies using sumoylation-deficient AR mutants suggest that the increase of AR activity by RAI17 is dependent upon receptor sumoylation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ00092 protein; PIAS-like protein Zimp10; retinoic acid induced 17; Retinoic acid-induced protein 17; RP11-519K18.1; Zinc finger MIZ domain-containing protein 1; zinc finger, MIZ-type containing 1; zinc finger-containing, Miz1, PIAS-like protein on chromosome 10
Gene Aliases: hZIMP10; KIAA1224; MIZ; RAI17; TRAFIP10; ZIMP10; ZMIZ1
UniProt ID: (Human) Q9ULJ6
Entrez Gene ID: (Human) 57178
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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