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Invitrogen
TFR2 Polyclonal Antibody
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Product Details
PA5-140257
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human TFR2. Recombinant protein control fragment (Product #RP-109320).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.
Immunogen sequence: SVLVVSEDVN YEPDLDFHQG RLYWSDLQAM FLQFLGEGRL EDTIRQTSLR ERVAGSAGMA ALTQDIRAAL SRQKLDHVWT DTHYVGLQFP DPAHPNTLHW VDEAGKVGEQ LPLEDPDVYC PYS
Highest antigen sequence indentity to the following orthologs: Rat - 80%, Mouse - 80%.
Target Information
This gene is a member of the transferrin receptor-like family and encodes a single-pass type II membrane protein with a protease associated (PA) domain, an M28 peptidase domain and a transferrin receptor-like dimerization domain. This protein mediates cellular uptake of transferrin-bound iron and mutations in this gene have been associated with hereditary hemochromatosis type III. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MGC126368; TfR2; Transferrin receptor protein 2
Gene Aliases: HFE3; TFR2; TFRC2
UniProt ID: (Human) Q9UP52
Entrez Gene ID: (Human) 7036
iron ion transport
cellular iron ion homeostasis
receptor-mediated endocytosis
response to iron ion
transferrin transport
positive regulation of endocytosis
positive regulation of transcription from RNA polymerase II promoter
iron ion homeostasis
cellular response to iron ion
positive regulation of peptide hormone secretion
ferrous iron import into cell
positive regulation of protein maturation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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