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Invitrogen
TDRD6 Polyclonal Antibody
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Product Details
PA5-140337
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human TDRD6. Recombinant protein control fragment (Product #RP-109513).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.
Immunogen sequence: INSSYKELKL LQSLTKTNLV TQYQDSVGNK NSQVFPLTTE KKEEISAETP LKTARVEATL SERKIGDSCD KDLPLKFCEF PQKTI
Highest antigen sequence indentity to the following orthologs: Rat - 53%, Mouse - 54%.
Target Information
Tudor domain-containing protein involved in germ cell development, more specifically the formation of chromatoid body (during spermiogenesis), Balbiani body (during oogenesis), germ plasm (upon fertilization), and for proper miRNA expression and spliceosome maturation. Essential for RNA-dependent helicase UPF1 localization to chromatoid body, for UPF1-UPF2 and UPF1-DDX4 interactions which are required for mRNA degradation, using the extended 3' UTR-triggered nonsense-mediated mRNA decay (NMD) pathway. Involved in spliceosome maturation and mRNA splicing in prophase I spermatocytes through interaction with arginine N-methyltransferase PRMT5 and symmetrically arginine dimethylated SNRPB (small nuclear ribonucleoprotein-associated protein).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Antigen NY-CO-45; Cancer/testis antigen 41.2; CT41.2; SPATA36; spermatogenesis associated 36; Tudor Domain Containing 6; Tudor domain-containing protein 6; tudor repeat 2
Gene Aliases: bA446F17.4; CT41.2; NY-CO-45; SPATA36; TDR2; TDRD6
UniProt ID: (Human) O60522
Entrez Gene ID: (Human) 221400
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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