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Invitrogen
TCF21 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-144734
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence. Antigen range: 125-179. Recombinant protein control fragment (Product #RP-109733).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.05 mg/mL
Amount
5 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: SSYIAHLRQI LANDKYENGY IHPVNLTWPF MVAGKPESDL KEVVTASRLC GTTAS
Antigen sequence identity: Mouse 96%; Rat 100%
Target Information
The basic helix-loop-helix transcription factor TCF21/Pod1 (also called capsulin or epicardin) is involved in kidney, lung and spleen organogenesis. It is also essential for normal development of the testes and ovaries. TCF21/Pod1 is involved in the transcriptional repression of steroidogenic factor 1 (Sf1/Nr5a1/Ad4BP), an orphan nuclear receptor that regulates the expression of multiple genes (including Scc) that mediate sexual differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: capsulin; class A basic helix-loop-helix protein 23; epicardin; pod-1; podocyte-expressed 1; TCF21
Gene Aliases: bHLHa23; POD1
UniProt ID: (Human) O43680
Entrez Gene ID: (Human) 6943
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
protein binding
histone deacetylase binding
bHLH transcription factor binding
protein dimerization activity
androgen receptor binding
E-box binding
sequence-specific double-stranded DNA binding
negative regulation of transcription from RNA polymerase II promoter
ureteric bud development
branching involved in ureteric bud morphogenesis
morphogenesis of a branching structure
kidney development
vasculature development
regulation of transcription from RNA polymerase II promoter
sex determination
branchiomeric skeletal muscle development
epithelial cell differentiation
developmental process
glomerulus development
positive regulation of transcription from RNA polymerase II promoter
lung alveolus development
spleen development
embryonic digestive tract morphogenesis
reproductive structure development
gland development
Sertoli cell differentiation
palate development
lung morphogenesis
lung vasculature development
bronchiole development
diaphragm development
respiratory system development
negative regulation of androgen receptor signaling pathway
metanephric mesenchymal cell differentiation
metanephric glomerular capillary formation
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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