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Invitrogen
CHP2 Polyclonal Antibody
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Product Details
PA5-144854
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence. Antigen range: 30-55. Recombinant protein control fragment (Product #RP-109801).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: RLHHRFRALD RNKKGYLSRM DLQQIG
Antigen sequence identity: Mouse 77%; Rat 77%
Target Information
CHP2 (Calcineurin B homologous protein 2), also known as Hepatocellular carcinoma-associated antigen 520, is a 196 amino acid protein that contains four EF-hand domains and plays a potential role in transmembrane Na+/H+ exchange. By binding to and activating NHE-1, CHP2 increases the pH and works to protect cells from serum deprivation-induced death. Though not typically detected in normal tissues, CHP2 is highly expressed in malignantly transformed cells and is therefore considered to be a tumor-associated antigen. Ectopic expression of CHP2 promotes proliferation of HEK293 cells and knockdown of CHP2 mRNA in HepG2 cells inhibits cell proliferation. Like calcineurin B, CHP2 can bind to and stimulate phosphatase activity of calcineurin A and activate the calcineurin/NFAT signaling pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Calcineurin B homologous protein 2; hepatocellular carcinoma antigen gene 520; Hepatocellular carcinoma-associated antigen 520; LCA520; unnamed protein product
Gene Aliases: CHP2; HCA520
UniProt ID: (Human) O43745
Entrez Gene ID: (Human) 63928
positive regulation of cell proliferation
positive regulation of phosphatase activity
protein transport
regulation of protein import into nucleus
positive regulation of protein import into nucleus
positive regulation of transcription from RNA polymerase II promoter
regulation of calcineurin-NFAT signaling cascade
positive regulation of calcineurin-NFAT signaling cascade
cellular response to calcium ion
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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