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Invitrogen
SH3PXD2B Polyclonal Antibody
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Product Details
PA5-144870
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence. Antigen range: 431-532. Recombinant protein control fragment (Product #RP-110002).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: ASRPNFLAPL PHEVTQLRLG EAAALENNTG SEATGPSRPL PDAPHGVMDS GLPWSKDWKG SKDVLRKASS DMSASAGYEE ISDPDMEEKP SLPPRKESII KS
Antigen sequence identity: Mouse 82%; Rat 83%
Target Information
Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Adapter protein HOFI; adaptor protein HOFI; Factor for adipocyte differentiation 49; FLJ20831; SH3 and PX domain-containing protein 2B; Tyrosine kinase substrate with four SH3 domains
Gene Aliases: FAD49; FTHS; HOFI; KIAA1295; SH3PXD2B; TKS4; TSK4
UniProt ID: (Human) A1X283
Entrez Gene ID: (Human) 285590
skeletal system development
eye development
superoxide metabolic process
heart development
extracellular matrix disassembly
cell differentiation
positive regulation of catalytic activity
positive regulation of fat cell differentiation
oxidation-reduction process
bone development
adipose tissue development
podosome assembly
protein localization to membrane
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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