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Invitrogen
IRF1 Polyclonal Antibody
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Product Details
PA5-144992
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence. Antigen range: 181-242. Recombinant protein control fragment (Product #RP-109923).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: PALSPCAVSS TLPDWHIPVE VVPDSTSDLY NFQVSPMPST SEATTDEDEE GKLPEDIMKL LE
Antigen sequence identity: Mouse 73%; Rat 77%
Target Information
IRF1 encodes interferon regulatory factor 1, a member of the interferon regulatory transcription factor (IRF) family. IRF1 serves as an activator of interferons alpha and beta transcription, and in mouse it has been shown to be required for double-stranded RNA induction of these genes. IRF1 also functions as a transcription activator of genes induced by interferons alpha, beta, and gamma. Further, IRF1 has been shown to play roles in regulating apoptosis and tumor-suppression. Diseases associated with IRF1 include gastric cancer, somatic and lung cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Interferon regulatory factor 1; IRF-1; IRF1; translated product has a 124 residue deletion in the C-terminal compared to NP002189.1; translated product has a 158 residue deletion in the C-terminal compared to NP002189.1; unnamed protein product
Gene Aliases: IMD117; IRF-1; IRF1; MAR
UniProt ID: (Human) P10914
Entrez Gene ID: (Human) 3659
transcription regulatory region sequence-specific DNA binding
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
sequence-specific DNA binding
immune system process
regulation of adaptive immune response
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
apoptotic process
negative regulation of cell proliferation
regulation of gene expression
positive regulation of type I interferon production
positive regulation of interferon-beta production
positive regulation of interleukin-12 production
regulation of MyD88-dependent toll-like receptor signaling pathway
cellular response to interferon-beta
CD8-positive, alpha-beta T cell differentiation
innate immune response
regulation of innate immune response
negative regulation of regulatory T cell differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
defense response to virus
regulation of cell cycle
interferon-gamma-mediated signaling pathway
cellular response to mechanical stimulus
regulation of CD8-positive, alpha-beta T cell proliferation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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