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Invitrogen
RAMP3 Polyclonal Antibody
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Product Details
PA5-145110
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence. Antigen range: 68-118. Recombinant protein control fragment (Product #RP-110144).
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: SFTNCTEMEA NVVGCYWPNP LAQGFITGIH RQFFSNCTVD RVHLEDPPDE V
Antigen sequence identity: Mouse 88%; Rat 90%
Target Information
The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP3) protein, CRLR functions as an adrenomedullin receptor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: calcitonin receptor-like receptor activity modifying protein 3; Calcitonin-receptor-like receptor activity-modifying protein 3; CRLR activity-modifying protein 3; RAMP3; receptor (calcitonin) activity modifying protein 3; receptor (G protein-coupled) activity modifying protein 3; Receptor activity-modifying protein 3; type I transmembrane protein; unnamed protein product
Gene Aliases: RAMP3
UniProt ID: (Human) O60896
Entrez Gene ID: (Human) 10268
positive regulation of receptor recycling
calcium ion transport
intracellular protein transport
G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
regulation of G-protein coupled receptor protein signaling pathway
positive regulation of gene expression
protein transport
receptor internalization
cellular response to hormone stimulus
cross-receptor inhibition within G protein-coupled receptor heterodimer
positive regulation of calcium-mediated signaling
positive regulation of protein kinase B signaling
positive regulation of ERK1 and ERK2 cascade
cellular response to estradiol stimulus
protein localization to plasma membrane
G-protein coupled receptor signaling pathway involved in heart process
amylin receptor signaling pathway
positive regulation of cAMP/PKA signal transduction
amylin receptor 3 signaling pathway
positive regulation of protein localization to plasma membrane
response to amyloid-beta
adrenomedullin receptor signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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