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Invitrogen
METTL3 Polyclonal Antibody
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Product Details
PA5-145227
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence. Antigen range: 480-574. Recombinant protein control fragment (Product #RP-109918).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: KEHCLVGVKG NPQGFNQGLD CDVIVAEVRS TSHKPDEIYG MIERLSPGTR KIELFGRPHN VQPNWITLGN QLDGIHLLDP DVVARFKQRY PDGII
Antigen sequence identity: Mouse 100%; Rat 98%
Target Information
METTL3 is the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involved in the posttranscriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: adoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase; hMETTL3; methyltransferase like 3; Methyltransferase-like protein 3; mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase; mRNA m(6)A methyltransferase; MT-A70; N(6)-adenosine-methyltransferase 70 kDa subunit; N(6)-adenosine-methyltransferase catalytic subunit METTL3; N6-adenosine-methyltransferase 70 kDa subunit; unnamed protein product
Gene Aliases: hMETTL3; IME4; M6A; METTL3; MT-A70; MTA70; Spo8
UniProt ID: (Human) Q86U44
Entrez Gene ID: (Human) 56339
mRNA splicing, via spliceosome
RNA methylation
immune system process
mRNA processing
mRNA export from nucleus
cellular response to DNA damage stimulus
spermatogenesis
circadian rhythm
dosage compensation by inactivation of X chromosome
mRNA modification
stem cell population maintenance
forebrain radial glial cell differentiation
cell differentiation
primary miRNA processing
methylation
cellular response to UV
gliogenesis
innate immune response
regulation of T cell differentiation
positive regulation of translation
negative regulation of Notch signaling pathway
oogenesis
rhythmic process
regulation of meiotic cell cycle
negative regulation of type I interferon-mediated signaling pathway
mRNA destabilization
endothelial to hematopoietic transition
regulation of hematopoietic stem cell differentiation
positive regulation of cap-independent translational initiation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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