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Invitrogen
OTC Polyclonal Antibody
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Product Details
PA5-51416
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human OTC. Recombinant protein control fragment (Product #RP-91883).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Amount
5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: QLKGRDLLTL KNFTGEEIKY MLWLSADLKF RIKQKGEYLP LLQGKSLGMI FEKRSTRTRL STETGFALLG GHPCFLTTQD IHLGVNESLT DTARVLSSMA DAVLAR
Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 97%.
Target Information
This nuclear gene encodes a mitochondrial matrix enzyme. Missense, nonsense, and frameshift mutations in this enzyme lead to ornithine transcarbamylase deficiency, which causes hyperammonemia. Since the gene for this enzyme maps close to that for Duchenne muscular dystrophy, it may play a role in that disease also.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Ornithine carbamoyltransferase, mitochondrial; Ornithine transcarbamylase, mitochondrial; OTCase; unnamed protein product
Gene Aliases: OCTD; OTC; OTC1; OTCase; OTCD
UniProt ID: (Human) P00480
Entrez Gene ID: (Human) 5009
urea cycle
liver development
cellular amino acid metabolic process
arginine biosynthetic process
ornithine metabolic process
ornithine catabolic process
midgut development
cellular amino acid biosynthetic process
response to xenobiotic stimulus
response to zinc ion
citrulline biosynthetic process
response to nutrient levels
response to insulin
arginine biosynthetic process via ornithine
anion homeostasis
response to biotin
ammonia homeostasis
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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