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Invitrogen
MNAT1 Polyclonal Antibody
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Product Details
PA5-51443
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human MNAT1. Recombinant protein control fragment (Product #RP-88898).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LDELESSDLP VALLLAQHKD RSTQLEMQLE KPKPVKPVTF STGIKMGQHI SLAPIHKLEE ALYEYQPLQI ETYGPHVPEL EMLGRLGYLN HVRAASPQDL AG
Highest antigen sequence identity to the following orthologs: Mouse - 91%, Rat - 92%.
Target Information
Progression through the cell cycle requires activation of a series of enzymes designated cyclin dependent kinases (Cdks). The monomeric catalytic subunit, Cdk2, a critical enzyme for initiation of cell cycle progression, is completely inactive. Partial activation is achieved by the binding of regulatory cyclins such as cyclin D1, while full activation requires phosphorylation at Thr 160. The enzyme responsible for phosphorylation of Thr 160 in Cdk2 and also Thr 161 in Cdc2 p34, designated Cdk-activating kinase (CAK), has been partially purified and shown to be comprised of a catalytic subunit, a regulatory subunit and a subunit of unknown function. The regulatory subunit is a novel cyclin (cyclin H) and is required for activation of Cdk7. This previously undescribed protein, now termed Mat1, has been cloned as a protein that associates with the cyclin H-Cdk7 nuclear complex at all stages of the cell cycle. Cyclin H-Cdk7-Mat1 complexes display kinase activity towards Cdk activation domains, and the carboxy terminus of RNA polymerase II. Mat1 appears to constitute the first example of an assembly factor, essential for the formation of an active Cdk-cyclin complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AdoMet synthetase; AMS1; CDK-activating kinase assembly factor MAT1; CDK7/cyclin-H assembly factor; cyclin G1 interacting protein; Cyclin-G1-interacting protein; EC 2.5.1.6; MAT-I/III; MATA1; Menage a trois; menage a trois 1 (CAK assembly factor); menage a trois homolog 1, cyclin H assembly factor; menage a trois-like protein 1 cyclin H assembly factor; MNAT CDK-activating kinase assembly factor 1; p35; p36; RING finger protein 66; RING finger protein MAT1
Gene Aliases: CAP35; MAT1; MNAT1; RNF66; TFB3
UniProt ID: (Human) P51948
Entrez Gene ID: (Human) 4331
regulation of cyclin-dependent protein serine/threonine kinase activity
G1/S transition of mitotic cell cycle
G2/M transition of mitotic cell cycle
DNA repair
transcription-coupled nucleotide-excision repair
nucleotide-excision repair, preincision complex assembly
regulation of transcription from RNA polymerase II promoter
transcription initiation from RNA polymerase I promoter
transcription elongation from RNA polymerase I promoter
termination of RNA polymerase I transcription
transcription from RNA polymerase II promoter
transcription initiation from RNA polymerase II promoter
transcription elongation from RNA polymerase II promoter
7-methylguanosine mRNA capping
protein complex assembly
protein phosphorylation
adult heart development
cell proliferation
ventricular system development
negative regulation of apoptotic process
positive regulation of transcription from RNA polymerase II promoter
positive regulation of smooth muscle cell proliferation
response to calcium ion
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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