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Invitrogen
CKAP4 Polyclonal Antibody
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Product Details
PA5-51455
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human CKAP4. Recombinant protein control fragment (Product #RP-93689).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LKDLSDGIHV VKDARERDFT SLENTVEERL TELTKSINDN IAIFTEVQKR SQKEINDMKA KVASLEESEG NKQDLKALKE AVKEIQTSAK SREWDMEALR STLQTMES
Highest antigen sequence identity to the following orthologs: Mouse - 83%, Rat - 33%.
Target Information
This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14. 7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 63 kDa membrane protein; 63-kDa cytoskeleton-linking membrane protein; Climp-63; Cytoskeleton-associated protein 4; transmembrane protein (63kD), endoplasmic reticulum/Golgi intermediate compartment; type-II transmembrane protein p63
Gene Aliases: 5630400A09Rik; CKAP4; CLIMP-63; ERGIC-63; P63
UniProt ID: (Human) Q07065, (Mouse) Q8BMK4
Entrez Gene ID: (Human) 10970, (Mouse) 216197, (Rat) 362859
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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