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Invitrogen
FGD1 Polyclonal Antibody
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Product Details
PA5-51482
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human FGD1. Recombinant protein control fragment (Product #RP-91933).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: DSDPGASEPG LLARRGSGSA LGGPLDPQFV GPSDTSLGAA PGHRVLPCGP SPQHHRALRF SYHLEGSQPR PGLHQGNRIL VKSLSLDPGQ SLEPHPEGPQ RLRSDP
Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 31%.
Target Information
FGD1 contains Dbl (DH) and pleckstrin (PH) homology domains. It can bind specifically to the Rho family GTPase Cdc42Hs and stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK/JNK1 activation. FGD1 has an essential role in embryonic development, and FGD1 gene mutations result in the human developmental disorder, Aarskog-Scott syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Faciogenital dysplasia 1 protein; FGD1; FYVE, RhoGEF and PH domain-containing protein 1; Rho/Rac GEF; Rho/Rac guanine nucleotide exchange factor FGD1; unnamed protein product; Zinc finger FYVE domain-containing protein 3
Gene Aliases: AAS; FGD1; FGDY; MRXS16; ZFYVE3
UniProt ID: (Human) P98174
Entrez Gene ID: (Human) 2245
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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