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Invitrogen
ANKLE2 Polyclonal Antibody
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Product Details
PA5-51973
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human ANKLE2. Recombinant protein control fragment (Product #RP-102178).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: SETVNKERAN SYKNPRTQDL TAKLRKAVEK GEEDTFSDLI WSNPRYLIGS GDNPTIVQEG CRYNVMHVAA KENQASICQL TLDVLENPDF MRLMYPDDDE AMLQKRIRYV VDLYLNTPDK MGYDTPLHFA CKFGNADVVN VLSSH
Highest antigen sequence identity to the following orthologs: Mouse - 91%, Rat - 90%.
Target Information
This gene encodes a human guanine nucleotide exchange factor. It transduces signals from CRK by binding the SH3 domain of CRK, and activating several members of the Ras family of GTPases. This signaling cascade that may be involved in apoptosis, integrin-mediated signal transduction, and cell transformation. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Ankyrin repeat and LEM domain-containing protein 2; LEM domain containing 7; LEM domain-containing protein 4
Gene Aliases: ANKLE2; KIAA0692; LEM4; LEMD7; MCPH16
UniProt ID: (Human) Q86XL3
Entrez Gene ID: (Human) 23141
mitotic nuclear division
mitotic nuclear envelope reassembly
central nervous system development
regulation of protein phosphatase type 2A activity
positive regulation of protein dephosphorylation
negative regulation of phosphorylation
negative regulation of apoptotic process
regulation of catalytic activity
cell division
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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