Search
Invitrogen
FAIM3 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
PA5-52019
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human FAIM3. Recombinant protein control fragment (Product #RP-102096).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: RGKTQKVTLN VHSEYEPSWE EQPMPETPKW FHLPYLFQMP AYASSSKFVT RVTTPAQRGK VPPVHHSSPT TQITHRPRVS RASSVAGDKP RTFLPSTTAS KISALEGLLK PQTPSYNHHT RLHRQRALDY GSQSGRE
Highest antigen sequence identity to the following orthologs: Mouse - 48%, Rat - 45%.
Target Information
Apoptosis is an important process by which normal tissue homeostasis and function are maintained. One of the major signals that regulate this process is mediated by the activation of the Fas receptor by its ligand. This leads to the formation of a Fas-associated death domain (FADD)- containing death-inducing signaling complex and the activation of caspase-8, which in turn activates downstream effector caspases, such as caspase-3 and -7. Recent experiments have shown that overexpression of Toso, a novel regulator of Fas-induced apoptosis in lymphoid cells, in Jurkat cells as well as transgenic mice render these cells resistant to Fas-induced apoptosis but not to TRAIL-induced apoptosis. Furthermore, Toso was found to associate with FADD, suggesting that Toso functions by disrupting the formation of the death-inducing signaling complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: FAIM3; Fas apoptotic inhibitory molecule 3; Fc fragment of IgM receptor; IgM Fc fragment receptor; IgM Fc receptor; IgM FcR; Immunoglobulin mu Fc receptor; Regulator of Fas-induced apoptosis Toso; transmembrane protein; Ig superfamily member; unnamed protein product
Gene Aliases: FAIM3; FCMR; FcmuR; IgM FcR; TOSO
UniProt ID: (Human) O60667
Entrez Gene ID: (Human) 9214
immune system process
immunoglobulin transcytosis in epithelial cells
humoral immune response mediated by circulating immunoglobulin
cellular defense response
signal transduction
Fc receptor signaling pathway
negative regulation of apoptotic process
regulation of B cell receptor signaling pathway
Fc receptor-mediated immune complex endocytosis
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support