Search
Invitrogen
AFG3L2 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
PA5-52080
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Dog
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human AFG3L2. Recombinant protein control fragment (Product #RP-102420).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: KTLLAKATAG EANVPFITVS GSEFLEMFVG VGPARVRDLF ALARKNAPCI LFIDEIDAVG RKRGRGNFGG QSEQENTLNQ LLVEMDGFNT TTNVVILAGT NRPDILDPAL LRPGRFDRQI FIGPPDIKGR ASIFKVHLRP LK
Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.
Target Information
AFG3L2 is a protein localized in mitochondria and closely related to paraplegin. The paraplegin gene is responsible for an autosomal recessive form of hereditary spastic paraplegia. AFG3L2 gene is a candidate gene for other hereditary spastic paraplegias or neurodegenerative disorders. This gene encodes a protein localized in mitochondria and closely related to paraplegin. The paraplegin gene is responsible for an autosomal recessive form of hereditary spastic paraplegia. This gene is a candidate gene for other hereditary spastic paraplegias or neurodegenerative disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: AFG3 ATPase family gene 3-like 2; AFG3 ATPase family member 3-like 2; AFG3 like AAA ATPase 2; AFG3-like protein 2; ATPase family gene 3, yeast; FLJ25993; Mitochondrial inner membrane m-AAA protease component AFG3L2; Paraplegin-like protein
Gene Aliases: AFG3L2; OPA12; SCA28; SPAX5
UniProt ID: (Human) Q9Y4W6
Entrez Gene ID: (Human) 10939
proteolysis
mitochondrion organization
axonogenesis
neuromuscular junction development
mitochondrial fusion
protein processing
protein autoprocessing
nerve development
protein catabolic process
membrane protein proteolysis
mitochondrial protein processing
calcium ion transmembrane import into mitochondrion
regulation of multicellular organism growth
cristae formation
myelination
mitochondrial calcium ion homeostasis
protein maturation
muscle cell development
righting reflex
cellular response to glutathione
regulation of calcium import into the mitochondrion
mitochondrial protein quality control
glutathione import into mitochondrion
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support