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Invitrogen
DAZAP1 Polyclonal Antibody
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Product Details
PA5-52083
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human DAZAP1. Recombinant protein control fragment (Product #RP-102467).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: STTQETLRSY FSQYGEVVDC VIMKDKTTNQ SRGFGFVKFK DPNCVGTVLA SRPHTLDGRN IDPKPCTPRG MQPERTRPKE GWQKGPRSDN SKSNKIFVGG IPHNCGETEL REYFKKFGVV TEVVMIYDAE KQRPR
Highest antigen sequence identity to the following orthologs: Mouse - 99%, Rat - 99%.
Target Information
The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors. The receptor is more than 90 kDa and has three major functional domains: the N-terminal domain, DNA-binding domain, and the androgen-binding domain. The androgen receptor is a ligand-activated transcription factor that binds active testosterone (T) and dihydrotestosterone (DHT). Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. The AR signaling pathway plays a key role in development and function of male reproductive organs, including the prostate and epididymis.AR also plays a role in nonreproductive organs, such as muscle, hair follicles, and brain.Androgen Receptor is a phosphoprotein, and also regulates mitogen-activated protein kinase (MAP kinase). The inhibition of the MEK1/2 pathway correlates directly with a change in phosphorylation state of the androgen receptor. Abnormalities in the AR signaling pathway have been linked to a number of diseases, including prostate cancer, Kennedy's disease, and male infertility. Mutations in this gene are associated with complete androgen insensitivity (CAIS).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: DAZ-associated protein 1; Deleted in azoospermia-associated protein 1; MGC19907; testicular tissue protein Li 50
Gene Aliases: 2410042M16Rik; DAZAP1; mPrrp
UniProt ID: (Human) Q96EP5, (Mouse) Q9JII5
Entrez Gene ID: (Human) 26528, (Mouse) 70248, (Rat) 362836
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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