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Invitrogen
Ankyrin 1 Polyclonal Antibody
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Product Details
PA5-52121
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human Ankyrin 1. Recombinant protein control fragment (Product #RP-102463).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: QNVMHIVRGS LCFVLKHIHQ ELDKELGESE GLSDDEETIS TRVVRRRVFL KGNEFQNIPG EQVTEEQFTD EQGNIVTKKI IRKVVRQIDL SSADAAQEHE EVELRGSGLQ PDLIEGRKGA QIVKRASLK
Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 53%.
Target Information
Ankyrins are a family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 1, the prototype of this family, was first discovered in the erythrocytes, but since has also been found in brain and muscles. Mutations in erythrocytic ankyrin 1 have been associated in approximately half of all patients with hereditary spherocytosis. Complex patterns of alternative splicing in the regulatory domain, giving rise to different isoforms of ankyrin 1 have been described. Truncated muscle-specific isoforms of ankyrin 1 resulting from usage of an alternate promoter have also been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ANK-1; ankyrin 1, erythrocytic; Ankyrin-1; Ankyrin-R; Erythrocyte ankyrin; rCG_43073
Gene Aliases: ANK; ANK1; SPH1; SPH2
UniProt ID: (Human) P16157
Entrez Gene ID: (Human) 286
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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