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Invitrogen
SCIMP Polyclonal Antibody
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Product Details
PA5-52254
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human SCIMP. Recombinant protein control fragment (Product #RP-88833).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: RRGKKWEIAK PLKHKQVDEE KMYENVLNES PVQLPPLPPR NWPSLEDSSP QEAPSQPPAT YSLVNKVKNK KTVSIPSYIE PEDDYDDVEI PANTE
Highest antigen sequence identity to the following orthologs: Mouse - 65%, Rat - 58%.
Target Information
SCIMP (SLP adaptor and Csk interacting membrane protein), also known as Nvl, is a palmitoylated transmembrane adaptor protein expressed in professional antigen presenting cells, most prominently in the lymph nodes and spleen. It is associated with tetraspanin-enriched microdomains (together with MHC II). There is a close relationship between SCIMP and tyrosinkinase Lyn, which is constitutively bound to it by its SH3 domain. After MHC II-mediated stimulation in the immunological synapse SCIMP becomes phosphorylated at several tyrosine residues and provides docking sites for Grb2 and SLP65 or SLP76 adaptors transducing the signal downstream, as well as for the kinase Csk with modulatory roles.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DTFT5783; SLP adapter and CSK-interacting membrane protein; SLP65/SLP76, Csk-interacting membrane protein; transmembrane protein C17orf87; unnamed protein product
Gene Aliases: C17orf87; SCIMP; UNQ5783; UNQ5783/PRO16090
UniProt ID: (Human) Q6UWF3
Entrez Gene ID: (Human) 388325
positive regulation of cytokine production involved in immune response
positive regulation of dendritic cell cytokine production
positive regulation of lipopolysaccharide-mediated signaling pathway
positive regulation of interleukin-12 production
positive regulation of interleukin-6 production
positive regulation of stress-activated MAPK cascade
toll-like receptor 3 signaling pathway
toll-like receptor 4 signaling pathway
toll-like receptor 7 signaling pathway
toll-like receptor TLR1:TLR2 signaling pathway
positive regulation of ERK1 and ERK2 cascade
cellular response to molecule of fungal origin
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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