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Invitrogen
RAB7 Polyclonal Antibody
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Product Details
PA5-52369
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
C. elegans,
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human RAB7. Recombinant protein control fragment (Product #RP-89503).
Conjugate
Form
Liquid
Concentration
0.20 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: CVLVFDVTAP NTFKTLDSWR DEFLIQASPR DPENFPFVVL GNKIDLENRQ VATKRAQAWC YSKNNIPYFE TSAKEAINVE QAFQTIARNA LKQETEVELY NEFPEPIKLD KNDRAK
Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 99%.
Target Information
RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport. Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. This gene encodes a RAB family member that regulates vesicle traffic in the late endosomes and also from late endosomes to lysosomes. This encoded protein is also involved in the cellular vacuolation of the VacA cytotoxin of Helicobacter pylori. Mutations at highly conserved amino acid residues in this gene have caused some forms of Charcot-Marie-Tooth (CMT) type 2 neuropathies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: rab-7; RAB7, member RAS oncogene family; Ras-associated protein RAB7; Ras-related protein BRL-RAS; Ras-related protein p23; Ras-related protein Rab-7a
Gene Aliases: PRO2706; RAB7; RAB7A
UniProt ID: (Human) P51149, (Mouse) P51150, (Rat) P09527
Entrez Gene ID: (Human) 7879, (Mouse) 19349, (Rat) 29448
protein targeting to lysosome
transport
intracellular protein transport
epidermal growth factor catabolic process
small GTPase mediated signal transduction
endosome to lysosome transport
protein transport
viral release from host cell
protein to membrane docking
Rab protein signal transduction
retrograde transport, endosome to Golgi
early endosome to late endosome transport
bone resorption
positive regulation of protein catabolic process
positive regulation of viral process
phagosome acidification
phagosome-lysosome fusion
positive regulation of exosomal secretion
regulation of autophagosome assembly
endocytosis
antigen processing and presentation of exogenous peptide antigen via MHC class II
lipophagy
phagosome maturation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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