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Invitrogen
PTPRN Polyclonal Antibody
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Product Details
PA5-52396
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein fragment of Human PTPRN (Product #RP-88661).
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: HSYGDLPGPS PAQLFQDSGL LYLAQELPAP SRARVPRLPE QGSSSRAEDS PEGYEKEGLG DRGEKPASPA VQPDAALQRL AAVLAGYGVE LRQLTPEQLS TLLTLLQLLP KGA
Highest antigen sequence identity to the following orthologs: Mouse - 77%, Rat - 81%.
Target Information
IA-2 (insulinoma-associated protein 2, ICA512, PTPRN) is a member of the transmembrane protein tyrosine phosphatase (PTP) family located in secretory granules of neuroendocrine cells. The IA-2 protein is 979 amino acids in length and consists of a luminal domain, transmembrane domain, and cytoplasmic domain. Although a member of the PTP family, IA-2 lacks phosphatase activity with known substrates due to amino acid substitutions at critical sites in its PTP domain. Two paralog RPTPs, IA-2 and IA-2beta were identified as major autoantigens in type-1 diabetes mellitus. On granule exocytosis, the IA-2 cytoplasmic domain is cleaved and the resulting cytosolic fragment moves into the nucleus where it enhances the levels of phosphorylated STAT5 and STAT3, thereby inducing insulin gene transcription and granule biogenesis. IA-2 signaling enhances pancreatic beta-cell proliferation by regulating cyclins D through STATs.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: IA-2var; ICA 512; insulinoma-associated tyrosine-phosphatase-like protein; islet cell antigen 2; Islet cell antigen 512; Islet cell autoantigen 3; protein tyrosine phosphatase-like N; PTP IA-2; R-PTP-N; Receptor-type tyrosine-protein phosphatase-like N; unnamed protein product
Gene Aliases: IA-2; IA-2/PTP; IA2; ICA3; ICA512; PTPRN; R-PTP-N
UniProt ID: (Human) Q16849
Entrez Gene ID: (Human) 5798
response to reactive oxygen species
luteinization
insulin secretion
insulin secretion involved in cellular response to glucose stimulus
positive regulation of transcription from RNA polymerase II promoter
regulation of secretion
positive regulation of type B pancreatic cell proliferation
dense core granule maturation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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