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Invitrogen
ZP4 Polyclonal Antibody
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Product Details
PA5-52577
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human ZP4. Recombinant protein control fragment (Product #RP-90149).
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: FAVNLNQEAT SPPVLIAWDN QGLLHELQND SDCGTWIRKG PGSSVVLEAT YSSCYVTEWD SHYIMPVGVE GAGAAEHKVV TERKLLKCPM DLLARDAPDT DWCDSIPA
Highest antigen sequence identity to the following orthologs: Mouse - 23%, Rat - 54%.
Target Information
The mammalian zona pellucida is composed of four major glycoproteins, ZP1, ZP2, ZP3 and ZP4, which may act as sperm receptors. Two forms of porcine ZP4 peptides exist: one consisting of 128 amino acid residues and the other of 133 amino acid residues. These two peptides are identical, except the larger form contains an additional five amino acid sequence at its carboxy-terminal end. Both peptides have two potential N-linked glycosylation sites. The smaller peptide shares 39.1% identity with the amino-terminal region of mouse ZP2 polypeptide. Based on results from animal studies, ZP4 antigen is a promising candidate for the development of a contraceptive vaccine.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Zona pellucida glycoprotein 4; Zona pellucida protein B; Zona pellucida sperm-binding protein 4; Zp-4
Gene Aliases: ZBP; Zp-4; ZP1; ZP4; ZPB
UniProt ID: (Human) Q12836
Entrez Gene ID: (Human) 57829
positive regulation of humoral immune response
binding of sperm to zona pellucida
protein kinase A signaling
intracellular signal transduction
positive regulation of T cell proliferation
positive regulation of protein kinase activity
acrosomal vesicle exocytosis
protein kinase C signaling
positive regulation of acrosome reaction
negative regulation of binding of sperm to zona pellucida
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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