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Invitrogen
RNF14 Polyclonal Antibody
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Product Details
PA5-52594
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human RNF14. Recombinant protein control fragment (Product #RP-102289).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: GCTMGICSSC NFAFCTLCRL TYHGVSPCKV TAEKLMDLRN EYLQADEANK RLLDQRYGKR VIQKALEEME SKEWLEKNSK SCPCCGTPIE KLDGCNKMTC TGCMQYFCWI CMGSLSRANP YKHFNDPGSP CFNRLFYAVD VDDDIWEDEV
Highest antigen sequence identity to the following orthologs: Mouse - 87%, Rat - 90%.
Target Information
The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Five alternatively spliced transcript variants encoding two distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: androgen receptor associated protein 54; Androgen receptor-associated protein 54; E3 ubiquitin-protein ligase RNF14; HFB30; HRIHFB2038; protein Triad2; RING finger protein 14; RNF14; triad2 protein; TRIAD2 type I; unnamed protein product
Gene Aliases: 2310075C09Rik; 2610005D23Rik; AA986456; ARA54; AU041447; D18Ertd188e; D7Bwg0165e; HFB30; HRIHFB2038; RNF14; TRIAD2
UniProt ID: (Human) Q9UBS8, (Mouse) Q9JI90
Entrez Gene ID: (Human) 9604, (Rat) 619577, (Mouse) 56736
transcription coactivator activity
ubiquitin-protein transferase activity
protein binding
zinc ion binding
transferase activity
ubiquitin-like protein transferase activity
ubiquitin conjugating enzyme binding
metal ion binding
androgen receptor binding
ubiquitin protein ligase activity
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ligase activity
ribosomal S6-glutamic acid ligase activity
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
ubiquitin-protein ligase
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
translational elongation
translational termination
ubiquitin-dependent protein catabolic process
signal transduction
protein ubiquitination
androgen receptor signaling pathway
positive regulation of transcription, DNA-templated
regulation of androgen receptor signaling pathway
regulation of canonical Wnt signaling pathway
rescue of stalled ribosome
protein K6-linked ubiquitination
protein-RNA covalent cross-linking repair
metabolic process
response to estradiol
transcription, DNA-templated
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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