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Invitrogen
SHOC2 Polyclonal Antibody
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Product Details
PA5-52659
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human SHOC2. Recombinant protein control fragment (Product #RP-89604).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LEENKLESLP NEIAYLKDLQ KLVLTNNQLT TLPRGIGHLT NLTHLGLGEN LLTHLPEEIG TLENLEELYL NDNPNLHSLP FELALCSKLS IMSIENCPLS HLPPQIVA
Highest antigen sequence identity to the following orthologs: Mouse - 99%, Rat - 100%.
Target Information
SHOC2 protein participates in protein binding / transferase activity in the fibroblast growth factor receptor signaling pathway and Ras protein signal transduction. It is a widely expressed protein composed almost entirely of leucine-rich repeats (LRR), with a lysine-rich sequence at the amino terminus and cytoplasmically localized. SHOC2 acts as a positive modulator of the RAS-MAPK signaling cascade, which is elicited by EGL-15 and LET-23 and mediated by LET-60. SHOC2 together with protein phosphatase 1c (PP1c) forms a highly specific M-Ras effector complex and is essential for activation of the MAPK pathway by growth factors. Furthermore, in tumor cells with Ras gene mutations, inhibition of SHOC2 expression inhibits MAPK, but not PI3K activity. The SHOC2-PP1c holoenzyme provides an attractive therapeutic target for inhibition of the MAPK pathway in cancer. Recent studies show that aberrantly acquired N-myristoylation of SHOC2 causes human disease Noonan-like syndrome with loose anagen hair.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Leucine-rich repeat protein SHOC-2; Protein soc-2 homolog; Protein sur-8 homolog; Ras-binding protein SUR-8; RP11-348N5.2; soc-2 (suppressor of clear) homolog; soc-2 suppressor of clear homolog; suppressor of clear, C. elegans, homolog of; unnamed protein product
Gene Aliases: AU017287; KIAA0862; mKIAA0862; NSLH1; SHOC2; SIAA0862; SOC2; SUR8
UniProt ID: (Human) Q9UQ13, (Mouse) O88520, (Rat) Q6AYI5
Entrez Gene ID: (Human) 8036, (Mouse) 56392, (Rat) 309548
fibroblast growth factor receptor signaling pathway
positive regulation of neuron projection development
intracellular signal transduction
nerve growth factor signaling pathway
regulation of MAPK cascade
negative regulation of neuron differentiation
positive regulation of neuron differentiation
positive regulation of Ras protein signal transduction
cellular response to growth hormone stimulus
cyclic-GMP-AMP transmembrane import across plasma membrane
negative regulation of neural precursor cell proliferation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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