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Invitrogen
GNA13 Polyclonal Antibody
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Product Details
PA5-52691
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human GNA13. Recombinant protein control fragment (Product #RP-90637).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: HGQDFDQRAR EEFRPTIYSN VIKGMRVLVD AREKLHIPWG DNSNQQHGDK MMSFDTRAPM AAQGMVETRV FLQYLPAIRA LWADSGIQNA YDRRREFQLG ES
Highest antigen sequence identity to the following orthologs: Mouse - 95%, Rat - 95%.
Target Information
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:15240885, PubMed:16787920, PubMed:16705036, PubMed:27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF and ARHGEF12/LARG) (PubMed:15240885, PubMed:12515866). GNA13-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway (PubMed:16787920, PubMed:16705036, PubMed:27084452). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (PubMed:11976333). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: G alpha 13; G alpha-13; G protein; Galpha 13; guanine nucleotide binding protein (G protein), alpha 13; Guanine nucleotide-binding protein subunit alpha-13; heterotrimeric guanine nucleotide-binding protein 1N; unnamed protein product
Gene Aliases: G13; GNA13; HG1N
UniProt ID: (Human) Q14344
Entrez Gene ID: (Human) 10672
angiogenesis
patterning of blood vessels
in utero embryonic development
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
Rho protein signal transduction
regulation of blood pressure
regulation of cell shape
regulation of fibroblast migration
cell differentiation
platelet activation
intracellular signal transduction
regulation of small GTPase mediated signal transduction
regulation of postsynapse assembly
Rho-activating G protein-coupled receptor signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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