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Invitrogen
PSTPIP1 Polyclonal Antibody
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Product Details
PA5-52712
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein fragment of Human PSTPIP1 (Product #RP-90639).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: GMIKRFSGLL HGSPKTTSLA ASAASTETLT PTPERNEGVY TAIAVQEIQG NPASPAQEYR ALYDYTAQNP DELDLSAGDI LEVILEGEDG WWTVERNGQR GFVPGSYLEK
Highest antigen sequence identity to the following orthologs: Mouse - 84%, Rat - 80%.
Target Information
PSTPIP1 is involved in regulation of the actin cytoskeleton. May regulate WAS actin-bundling activity. Bridges the interaction between ABL1 and PTPN18 leading to ABL1 dephosphorylation. May play a role as a scaffold protein between PTPN12 and WAS and allow PTPN12 to dephosphorylate WAS. Has the potential to physically couple CD2 and CD2AP to WAS. Acts downstream of CD2 and CD2AP to recruit WAS to the T-cell:APC contact site so as to promote the actin polymerization required for synapse induction during T-cell activation. Down-regulates CD2-stimulated adhesion through the coupling of PTPN12 to CD2. Also has a role in innate immunity and the inflammatory response. Recruited to inflammasomes by MEFV. Induces formation of pyroptosomes, large supramolecular structures composed of oligomerized PYCARD dimers which form prior to inflammatory apoptosis. Binding to MEFV allows MEFV to bind to PYCARD and facilitates pyroptosome formation. Regulates endocytosis and cell migration in neutrophils.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD2 antigen-binding protein 1; CD2 cytoplasmic tail-binding protein; CD2-binding protein 1; H-PIP; PEST phosphatase-interacting protein 1; Proline-serine-threonine phosphatase-interacting protein 1; similar to Mus musculus PEST phosphatase interacting protein, encoded by GenBank Accession Number U87814; unnamed protein product
Gene Aliases: AICZC; CD2BP1; CD2BP1L; CD2BP1S; H-PIP; PAPA; PAPAS; PSTPIP; PSTPIP1
UniProt ID: (Human) O43586
Entrez Gene ID: (Human) 9051
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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