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Product Details
PA5-53023
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Non-human primate,
Rabbit
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human VAPB. Recombinant protein control fragment (Product #RP-90173).
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Amount
30 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: VWKEAKPEDL MDSKLRCVFE LPAENDKPHD VEINKIISTT ASKTETPIVS KSLSSSLDDT EVKKVMEECK RLQGEVQRLR EENKQFKEED GLRMRKTVQS NSPISALAPT GK
Highest antigen sequence identity to the following orthologs: Mouse - 82%, Rat - 79%.
Target Information
Vesicle-associated membrane protein-associated protein B/C is a protein that in humans is encoded by the VAPB gene. The VAPB gene is found on the 20th human chromosome. The protein encoded by this gene is a type IV membrane protein found in plasma and intracellular vesicle membranes. The encoded protein is found as a homodimer and as a heterodimer with VAPA. This protein also can interact with VAMP1 and VAMP2 and may be involved in vesicle trafficking.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ALS 8; ALS8VAMP-B/VAMP-C; splice variant of VAPB; unnamed protein product; vamp; VAMP (vesicle-associated membrane protein)-associated protein B and C; Vamp 33b; VAMP B; VAMP B VAMP C; VAMP B/VAMP C; VAMP C; VAMP-associated 33 kDa protein; VAMP-associated protein 33b; VAMP-associated protein B; VAMP-B; VAMP-B/VAMP-C; VAMP-C; VAMPB; VAMPB/VAMPC; VAMPC; VAP 33b; VAP B; VAP B/VAP C; VAP C; VAP-33; VAP-B; VAP-B/VAP-C; VAP-C; VAPB/VAPC; VAPC; vesicle-associated membrane protein, associated protein B and C; Vesicle-associated membrane protein-associated protein B; Vesicle-associated membrane protein-associated protein B/C
Gene Aliases: AI225786; AI840687; AI848259; ALS8; D2Abb2e; R75548; UNQ484/PRO983; VAMP-B; Vamp33b; VAP-B; VAP33b; VAPB
UniProt ID: (Human) O95292, (Rat) Q9Z269
Entrez Gene ID: (Human) 9217, (Rat) 60431, (Mouse) 56491
cellular calcium ion homeostasis
ER to Golgi vesicle-mediated transport
response to unfolded protein
endoplasmic reticulum organization
viral release from host cell
cholesterol transport
endoplasmic reticulum unfolded protein response
IRE1-mediated unfolded protein response
negative regulation by host of viral release from host cell
negative regulation by host of viral genome replication
positive regulation by host of viral genome replication
modulation by host of viral RNA genome replication
positive regulation of viral genome replication
negative regulation by virus of viral protein levels in host cell
endoplasmic reticulum-plasma membrane tethering
COPII-coated vesicle budding
endoplasmic reticulum membrane organization
activation of signaling protein activity involved in unfolded protein response
biological_process
modulation by virus of host morphology or physiology
positive regulation by host of viral release from host cell
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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