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Invitrogen
SLC6A1 Polyclonal Antibody
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Product Details
PA5-53045
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human SLC6A1. Recombinant protein control fragment (Product #RP-102433).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: IYYLYNSFTT TLPWKQCDNP WNTDRCFSNY SMVNTTNMTS AVVEFWERNM HQMTDGLDKP G
Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 98%.
Target Information
GAT-1 (SLC6A1) The protein encoded by SLC6A1 is a gamma-aminobutyric acid (GABA) transporter that localizes to the plasma membrane. The encoded protein removes GABA from the synaptic cleft, restoring it to presynaptic terminals.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GABA T-1; GABA T1; GABA transporter 1; GABA transporter protein; GABAT1; gamma-aminobutyric acid (GABA-A) transporter 1; GAT-1; Sodium- and chloride-dependent GABA transporter 1; solute carrier family 6 (neurotransmitter transporter), member 1; solute carrier family 6 (neurotransmitter transporter, GABA), member 1; Solute carrier family 6 member 1; unnamed protein product
Gene Aliases: A730043E01; GABATHG; GABATR; Gabt; GABT1; GAT-1; GAT1; hGAT-1; MAE; SLC6A1; XT-1; Xtrp1
UniProt ID: (Human) P30531, (Rat) P23978, (Mouse) P31648
Entrez Gene ID: (Human) 6529, (Rat) 79212, (Mouse) 232333
sodium:amino acid symporter activity
gamma-aminobutyric acid:sodium symporter activity
protein binding
gamma-aminobutyric acid transmembrane transporter activity
symporter activity
sodium:chloride symporter activity
transmembrane transporter activity
metal ion binding
neurotransmitter:sodium symporter activity
primary active transporter
amino acid transmembrane transport
neurotransmitter transport
amino acid transport
chemical synaptic transmission
memory
associative learning
sodium ion transmembrane transport
synapse organization
gamma-aminobutyric acid reuptake
gamma-aminobutyric acid import
inorganic anion import across plasma membrane
sodium ion import across plasma membrane
neurotransmitter reuptake
transport across blood-brain barrier
chloride transmembrane transport
learning
response to toxic substance
response to sucrose
response to organic substance
response to organonitrogen compound
response to lead ion
positive regulation of gamma-aminobutyric acid secretion
response to organic cyclic compound
response to purine-containing compound
negative regulation of synaptic transmission, GABAergic
response to estradiol
response to cocaine
protein homooligomerization
response to calcium ion
transmembrane transport
transport
mitophagy in response to mitochondrial depolarization
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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