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Invitrogen
MYOM1 Polyclonal Antibody
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Product Details
PA5-53143
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human MYOM1. Recombinant protein control fragment (Product #RP-90711).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: GITDTEEERI KEAAAYIAQR NLLASEEGIT TPKQSTASKQ TTASKQSTAS KQSTASKQST ASRQSTASRQ SVVSKQATSA LQQEETSEKK SRKVVIREKA ERLSLRKTLE ETETYHAKLN EDHLLHAPEF IIKPRSHTVW EKENV
Highest antigen sequence identity to the following orthologs: Mouse - 64%, Rat - 81%.
Target Information
The giant protein titin, together with its associated proteins, interconnects the major structure of sarcomeres, the M bands and Z discs. The C-terminal end of the titin string extends into the M line, where it binds tightly to M-band constituents of apparent molecular masses of 190 kD (myomesin 1) and 165 kD (myomesin 2). This protein, myomesin 1, like myomesin 2, titin, and other myofibrillar proteins contains structural modules with strong homology to either fibronectin type III (motif I) or immunoglobulin C2 (motif II) domains. Myomesin 1 and myomesin 2 each have a unique N-terminal region followed by 12 modules of motif I or motif II, in the arrangement II-II-I-I-I-I-I-II-II-II-II-II. The two proteins share 50% sequence identity in this repeat-containing region. The head structure formed by these 2 proteins on one end of the titin string extends into the center of the M band. The integrating structure of the sarcomere arises from muscle-specific members of the superfamily of immunoglobulin-like proteins. Alternatively spliced transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 190 kDa connectin-associated protein; 190 kDa titin-associated protein; EH-myomesin; myomesin (M-protein) 1 (190kD); myomesin 1 (skelemin) 185kDa; myomesin 1, 185kDa; Myomesin family member 1; Myomesin-1; unnamed protein product
Gene Aliases: MYOM1; SKELEMIN
UniProt ID: (Human) P52179
Entrez Gene ID: (Human) 8736
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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