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Invitrogen
PKP2 Polyclonal Antibody
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Product Details
PA5-53144
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human PKP2. Recombinant protein control fragment (Product #RP-89628).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: VGNGNLHRTS SVPEYVYNLH LVENDFVGGR SPVPKTYDML KAGTTATYEG RWGRGTAQYS SQKSVEERSL RHPLRRLEIS PDSSPERAHY THSDYQYSQR SQAGHTLHHQ ESRRAALLVP PRY
Highest antigen sequence identity to the following orthologs: Mouse - 65%, Rat - 41%.
Target Information
Plakophilins 1, 2, 3 and 4 (PKP1-4) influence development and participate in linking cadherins to cytoskeletal intermediate filaments. Plakophilins 1-4 contain arm-repeat (armadillo) domains and localize to nuclei and cell desmosomes (cell-cell junctions found in suprabasal layers of stratifying epithelia that undergo mechanical stress). Plakophilin 1 mediates increases in desmosomal protein content, desmosome assembly and regulation of cell migration. Plakophilin 2 is important for desmosome assembly and is an essential morphogenic factor and architectural component of the heart. Plakophilin 4 is a component of desmosomal adhesion plaques that regulates junctional plaque organization and cadherin function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: desmosomal protein; K112N; desmosomal protein; Q62DfsX22; desmosomal protein; T816RfsX9; desmosomal protein; V587I; Plakophilin-2; unnamed protein product
Gene Aliases: ARVD9; PKP2
UniProt ID: (Human) Q99959
Entrez Gene ID: (Human) 5318
desmosome assembly
desmosome organization
cell adhesion
cell-cell signaling
heart development
positive regulation of sodium ion transport
regulation of cell-substrate adhesion
intermediate filament bundle assembly
maintenance of organ identity
ventricular cardiac muscle tissue morphogenesis
protein localization to plasma membrane
cardiac muscle cell action potential involved in contraction
ventricular cardiac muscle cell action potential
cell communication by electrical coupling involved in cardiac conduction
bundle of His cell-Purkinje myocyte adhesion involved in cell communication
regulation of heart rate by cardiac conduction
cell-cell adhesion
regulation of ventricular cardiac muscle cell action potential
maintenance of protein localization at cell tip
regulation of substrate adhesion-dependent cell spreading
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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