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Invitrogen
Aquaporin 4 Polyclonal Antibody
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Product Details
PA5-53234
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
C. elegans,
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human Aquaporin 4. Recombinant protein control fragment (Product #RP-91109).
Conjugate
Form
Liquid
Concentration
0.30 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: CPDVEFKRRF KEAFSKAAQQ TKGSYMEVED NRSQVETDDL ILKPGVVHVI DVDRGEEKKG KDQSGEVLSS V
Highest antigen sequence identity to the following orthologs: Mouse - 93%, Rat - 92%.
Target Information
In skeletal muscle, AQP4 (aquaporin 4 also known as mercurial insensitive water channel), localizes to the sarcolemma of fast-twitch muscle fibers. Aquaporins (AQPs) are a large family of integral membrane water transport channel proteins that facilitate the transport of water through the cell membrane. This function is conserved in animals, plants and bacteria. Many isoforms of aquaporin have been identified in mammals, designated AQP0 through AQP10. Aquaporins are widely distributed and it is not uncommon for more than one type of AQP to be present in the same cell. Although most aquaporins are only permeable to water, AQP3, AQP7, AQP9 and one of the two AQP10 transcripts are also permeable to urea and glycerol.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: AQP-4; aquaporin type4; Aquaporin-4; Aquaporin4; HMIWC2; Mercurial-insensitive water channel; MGC22454; MIWC; WCH4
Gene Aliases: AQP4; MIWC; WCH4
UniProt ID: (Human) P55087, (Mouse) P55088
Entrez Gene ID: (Human) 361, (Mouse) 11829
renal water homeostasis
transport
water transport
cellular water homeostasis
glycerol transport
ion transmembrane transport
multicellular organismal water homeostasis
cellular response to interferon-gamma
sensory perception of sound
regulation of vascular endothelial growth factor production
carbon dioxide transport
water homeostasis
negative regulation of interleukin-1 beta production
negative regulation of interleukin-6 production
carbohydrate transmembrane transport
protein homooligomerization
transmembrane transport
negative regulation of cell adhesion molecule production
renal water absorption
cellular response to glucose stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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