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Invitrogen
SRPK2 Polyclonal Antibody
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Product Details
PA5-53315
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human SRPK2. Recombinant protein control fragment (Product #RP-91439).
Conjugate
Form
Liquid
Concentration
0.10 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: QQLDDEDDDE EDCPNPEEYN LDEPNAESDY TYSSSYEQFN GELPNGRHKI PESQFPEFST SLFSGSLEPV ACGSVLSEGS PLTEQEESSP SHDRSRTVSA SSTGDLPKAK TRAADLLVNP L
Highest antigen sequence identity to the following orthologs: Mouse - 86%, Rat - 83%.
Target Information
SRPK2, along with SRPK1, is most likely the cellular protein kinase mediating HBV core protein phosphorylation during viral infection. It therefore represents an important host cell target for therapeutic intervention in HBV infection. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up-regulation. Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23/PRP28. Plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles .
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: H_RG152G17.1a; H_RG152G17.1b; serine kinase SRPK2; Serine/arginine-rich protein-specific kinase 2; serine/arginine-rich splicing factor kinase 2; serine/threonine-protein kinase SRPK2; SFRS protein kinase 2; SR protein kinase 2; SR-protein-specific kinase 2; SRPK2; SRSF protein kinase 2; WUGSC:H_RG152G17.1a
Gene Aliases: SFRSK2; SRPK2
UniProt ID: (Human) P78362
Entrez Gene ID: (Human) 6733
spliceosomal complex assembly
angiogenesis
protein phosphorylation
positive regulation of cell proliferation
RNA splicing
positive regulation of gene expression
cell differentiation
nuclear speck organization
intracellular signal transduction
positive regulation of neuron apoptotic process
positive regulation of viral genome replication
negative regulation of viral genome replication
innate immune response
positive regulation of cell cycle
regulation of mRNA splicing, via spliceosome
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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