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Invitrogen
SCNN1B Polyclonal Antibody
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Product Details
PA5-53342
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human SCNN1B. Recombinant protein control fragment (Product #RP-90439).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: GIYAMSGTET SIGVLVDKLQ RMGEPYSPCT VNGSEVPVQN FYSDYNTTYS IQACLRSCFQ DHMIRNCNCG HYLYPLPRGE KYCNNRDFPD WAHCYSDLQM SVAQRETCIG MCKESCNDTQ YKMTISMADW PSEASEDWIF HVLS
Highest antigen sequence identity to the following orthologs: Mouse - 87%, Rat - 88%.
Target Information
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. Heterotetramer of two alpha, one beta and one gamma subunit. A delta subunit can replace the alpha subunit. Interacts with the WW domains of NEDD4, NEDD4L, WWP1 and WWP2. Defects in SCNN1B are a cause of autosomal recessive pseudohypoaldosteronism type 1 (PHA1) [MIM:264350]. PHA1 is a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. There are 2 forms of PHA1: the autosomal recessive form that is severe, and the dominant form which is more milder and due to defects in mineralocorticoid receptor. Autosomal recessive PHA1 is characterized by an often fulminant presentation in the neonatal period with dehydration, hyponatraemia, hyperkalaemia, metabolic acidosis, failure to thrive and weight loss. Defects in SCNN1B are a cause of Liddle syndrome. It is an autosomal dominant disorder characterized by pseudoaldosteronism and hypertension associated with hypokalemic alkalosis. The disease is caused by constitutive activation of the renal epithelial sodium channel.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Amiloride-sensitive sodium channel subunit beta; amiloride-sensitive sodium channel subunit beta 1; Beta ENaC; Beta-ENaC; Beta-NaCH; ENaC subunit beta; ENaC; sodium channel beta-2; epithelial Na(+) channel subunit beta; epithelial sodium channel beta-2 subunit; epithelial sodium channel beta-3 subunit; Epithelial sodium channel subunit beta; mutant sodium channel epithelial 1 beta subunit; nasal ENaC; hnENac; nasal epithelial sodium channel beta subunit; Nonvoltage-gated sodium channel 1 subunit beta; SCNEB; SCNN 1B; sodium channel epithelial 1 beta subunit; sodium channel, non-voltage-gated 1, beta subunit; unnamed protein product
Gene Aliases: BESC1; beta-ENaC; beta-NaCH; ENaCb; ENaCbeta; LIDLS1; PHA1B2; SCNEB; SCNN1B
UniProt ID: (Human) P51168
Entrez Gene ID: (Human) 6338
leukocyte activation involved in inflammatory response
neutrophil activation involved in immune response
renal system process
ion transport
sodium ion transport
cellular sodium ion homeostasis
regulation of blood pressure
response to xenobiotic stimulus
gene expression
artery smooth muscle contraction
response to food
aldosterone metabolic process
erythrocyte homeostasis
ion transmembrane transport
multicellular organism growth
sodium ion transmembrane transport
epithelial fluid transport
multicellular organismal water homeostasis
sensory perception of salty taste
sensory perception of sour taste
potassium ion homeostasis
sodium ion homeostasis
mucus secretion
neutrophil mediated killing of bacterium
cellular response to acidic pH
sodium ion import across plasma membrane
cellular response to aldosterone
cellular response to vasopressin
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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