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Invitrogen
PTPN23 Polyclonal Antibody
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Product Details
PA5-53504
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human PTPN23. Recombinant protein control fragment (Product #RP-91555).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: VLDQFMDSMQ LDPETVDNLD AYSHIPPQLM EKCAALSVRP DTVRNLVQSM QVLSGVFTDV EASLKDIRDL LEEDELLEQK FQEAVGQAGA ISITSKAELA EVRREWAKYM EVHEKASFTN SELHRAMNLH VGN
Highest antigen sequence identity to the following orthologs: Mouse - 90%, Rat - 89%.
Target Information
Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes. May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HD-PTP; His domain-containing protein tyrosine phosphatase; Protein tyrosine phosphatase TD14; PTP-TD14; Tyrosine-protein phosphatase non-receptor type 23; unnamed protein product
Gene Aliases: HD-PTP; HDPTP; KIAA1471; NEDBASS; PTP-TD14; PTPN23
UniProt ID: (Human) Q9H3S7
Entrez Gene ID: (Human) 25930
negative regulation of epithelial cell migration
protein transport
cell projection organization
endocytic recycling
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
early endosome to late endosome transport
cilium morphogenesis
positive regulation of Wnt protein secretion
positive regulation of homophilic cell adhesion
positive regulation of adherens junction organization
positive regulation of early endosome to late endosome transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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