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Invitrogen
Cbl-b Polyclonal Antibody
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Product Details
PA5-53783
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human Cbl-b. Recombinant protein control fragment (Product #RP-91841).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: PPGSSSRPSS GQDLFLLPSD PFVDLASGQV PLPPARRLPG ENVKTNRTSQ DYDQLPSCSD GSQAPARPPK PRPRRTAPEI HHRKP
Highest antigen sequence identity to the following orthologs: Mouse - 87%, Rat - 91%.
Target Information
This gene encodes a protein of unknown function. The protein contains a bromodomain, a sequence motif often found in transcriptional coactivators, and localizes to the nucleus in testis and several other cell types.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cas-Br-M (murine) ecotropic retroviral transforming sequence b; Casitas B-lineage lymphoma proto-oncogene b; Cbl proto-oncogene B, E3 ubiquitin protein ligase; Cbl proto-oncogene, E3 ubiquitin protein ligase B; E3 ubiquitin-protein ligase CBL-B; RING finger protein 56; RING-type E3 ubiquitin transferase CBL-B; SH3-binding protein CBL-B; Signal transduction protein CBL-B; unnamed protein product
Gene Aliases: ADMIO3; Cbl-b; CBLB; Nbla00127; RNF56
UniProt ID: (Human) Q13191
Entrez Gene ID: (Human) 868
positive regulation of T cell anergy
T cell anergy
NLS-bearing protein import into nucleus
immune response
signal transduction
cell surface receptor signaling pathway
protein ubiquitination
regulation of signaling
regulation of cell adhesion
protein catabolic process
positive regulation of protein ubiquitination
intracellular signal transduction
CD4-positive, alpha-beta T cell proliferation
negative regulation of epidermal growth factor receptor signaling pathway
T cell activation
positive regulation of protein catabolic process
T cell receptor signaling pathway
negative regulation of T cell receptor signaling pathway
regulation of postsynaptic neurotransmitter receptor internalization
regulation protein catabolic process at postsynapse
negative regulation of CD4-positive, alpha-beta T cell proliferation
regulation of platelet-derived growth factor receptor-alpha signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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