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Invitrogen
KPNA6 Polyclonal Antibody
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Product Details
PA5-53867
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human KPNA6. Recombinant protein control fragment (Product #RP-91826).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: RRREEEGIQL RKQKREQQLF KRRNVELINE EAAMFDSLLM DSYVSSTTGE SVITREMVEM LFSDDSDLQL ATTQKFR
Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.
Target Information
Karyopherin, a cytosolic and heterodimeric protein complex consisting of alpha and beta subunits, is responsible for targeting proteins with nuclear localization signals to the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. The alpha subunit and imported substrate enter the nucleus and accumulate in the nucleoplasm, while the beta subunit accumulates at the NPC. KPNA6 belongs to a subfamily within the KPNA family that also includes IPOA5&6. Down-regulation of KPNA6 by RNAi expression in HeLa cells strongly inhibited cell proliferation, possibly due to blocking the nuclear import of specific factors essential for cell growth and proliferation. KPNA6 also interacts with the Rev protein of HIV-1 and promote its nuclear import.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ11249; importin alpha 7 subunit; Importin subunit alpha-7; importin-alpha-S2; karyopherin alpha 6; karyopherin alpha 6 (importin alpha 7); Karyopherin subunit alpha-6; MGC17918; RP4-622L5.1; unnamed protein product
Gene Aliases: IPOA7; KPNA6
UniProt ID: (Human) O60684
Entrez Gene ID: (Human) 23633
transcription from RNA polymerase II promoter
protein import into nucleus
NLS-bearing protein import into nucleus
protein transport
viral genome replication
positive regulation of transcription from RNA polymerase II promoter
maternal process involved in female pregnancy
entry of viral genome into host nucleus through nuclear pore complex via importin
positive regulation of cytokine production involved in inflammatory response
positive regulation of viral life cycle
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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