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Invitrogen
GLTSCR2 Polyclonal Antibody
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Product Details
PA5-53888
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human GLTSCR2. Recombinant protein control fragment (Product #RP-92581).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: REAEADKPRR LGRLKYQAPD IDVQLSSELT DSLRTLKPEG NILRDRFKSF QRRNMIEPRE RAKFKRKYKV KLVEKRAFRE IQL
Highest antigen sequence identity to the following orthologs: Mouse - 93%, Rat - 95%.
Target Information
Nucleolar protein which is involved in the integration of the 5S RNP into the ribosomal large subunit during ribosome biogenesis. In ribosome biogenesis, may also play a role in rRNA transcription. Also functions as a nucleolar sensor that regulates the activation of p53/TP53 in response to ribosome biogenesis perturbation, DNA damage and other stress conditions. DNA damage or perturbation of ribosome biogenesis disrupt the interaction between NOP53 and RPL11 allowing RPL11 transport to the nucleoplasm where it can inhibit MDM2 and allow p53/TP53 activation. It may also positively regulate the function of p53/TP53 in cell cycle arrest and apoptosis through direct interaction, preventing its MDM2-dependent ubiquitin-mediated proteasomal degradation. Originally identified as a tumor suppressor, it may also play a role in cell proliferation and apoptosis by positively regulating the stability of PTEN, thereby antagonizing the PI3K-AKT/PKB signaling pathway. May also inhibit cell proliferation and increase apoptosis through its interaction with NF2. May negatively regulate NPM1 by regulating its nucleoplasmic localization, oligomerization and ubiquitin-mediated proteasomal degradation. Thereby, may prevent NPM1 interaction with MYC and negatively regulate transcription mediated by the MYC-NPM1 complex. May also regulate cellular aerobic respiration. In the cellular response to viral infection, may play a role in the attenuation of interferon-beta through the inhibition of DDX58/RIG-1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Glioma tumor suppressor candidate region gene 2 protein; p60; PICT-1; Protein interacting with carboxyl terminus 1; Ribosome biogenesis protein NOP53; unnamed protein product; viral protein-binding protein; PreS1BP
Gene Aliases: GLT; GLTSCR2; NOP53; PICT-1; PICT1
UniProt ID: (Human) Q9NZM5
Entrez Gene ID: (Human) 29997
ribosomal large subunit assembly
negative regulation of transcription from RNA polymerase II promoter
regulation of protein phosphorylation
DNA repair
rRNA processing
cellular response to DNA damage stimulus
mitotic G2 DNA damage checkpoint
negative regulation of protein complex assembly
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
regulation of RIG-I signaling pathway
ribosome biogenesis
regulation of apoptotic process
protein stabilization
regulation of cell cycle
negative regulation of protein kinase B signaling
cellular response to hypoxia
regulation of signal transduction by p53 class mediator
negative regulation of signal transduction by p53 class mediator
negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter
protein localization to nucleolus
positive regulation of protein K63-linked deubiquitination
regulation of aerobic respiration
protein localization to nucleoplasm
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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