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Invitrogen
WIPI2 Polyclonal Antibody
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Product Details
PA5-54098
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human WIPI2. Recombinant protein control fragment (Product #RP-92773).
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: ECALMKQHRL DGSLETTNEI LDSASHDCPL VTQTYGAAAG KGTYVPSSPT RLAYTDDLGA VGGACLEDEA SALRLDEDSE HPPMILRTD
Highest antigen sequence identity to the following orthologs: Mouse - 83%, Rat - 84%.
Target Information
WD repeat proteins play a role in many essential biologic functions, regulating the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. WIPI2, also known as ATG18B or ATG21, is a human homolog to yeast ATG18 and contains three WD repeats and has a 7-bladed propeller structure with a conserved motif that facilitates its interaction with other proteins. It is recruited to early autophagosomal structures along with Atg16L and ULK1 and is required for the formation of LC3-positive autophagosomes. Along with the highly related WIPI1, WIPI2 is found at the plasma membrane in addition to autophagosomal membranes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: WD repeat domain phosphoinositide-interacting protein 2; WD40 repeat protein interacting with phosphoinositides 2; WIPI-2; WIPI49-like protein 2
Gene Aliases: 1110018O08Rik; 2510001I10Rik; ATG18B; Atg21; CGI-50; WIPI-2; WIPI2
UniProt ID: (Human) Q9Y4P8, (Mouse) Q80W47, (Rat) Q6AY57
Entrez Gene ID: (Human) 26100, (Mouse) 74781, (Rat) 288498
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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