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Invitrogen
CaV1.3 Polyclonal Antibody
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Product Details
PA5-54163
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human Calcium Channel 1D. Recombinant protein control fragment (Product #RP-102095).
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: EDPEIHGYFR DPHCLGEQEY FSSEECYEDD SSPTWSRQNY GYYSRYPGRN IDSERPRGYH HPQGFLEDDD SPVCYDSRRS PRRRLLPPTP ASHRRSSFNF ECLRRQSSQE EVPSSPIFPH RTALPLHLMQ QQIMAV
Highest antigen sequence identity to the following orthologs: Mouse - 87%, Rat - 85%.
Target Information
CACNA1D is also known as PASNA, SANDD or Cav1. 3. Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, namely alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1D subunit. Several transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CACNA 1D; calcium channel, L type, alpha-1 polypeptide; Calcium channel, L type, alpha-1 polypeptide, isoform 2; calcium channel, neuroendocrine/brain-type, alpha 1 subunit; calcium channel, voltage-dependent, L type, alpha 1D subunit; unnamed protein product; Voltage-dependent L-type calcium channel subunit alpha-1D; voltage-gated calcium channel alpha 1 subunit; voltage-gated calcium channel alpha subunit Cav1.3; Voltage-gated calcium channel subunit alpha Cav1.3
Gene Aliases: CACH3; CACN4; CACNA1D; CACNL1A2; Cav1.3; CCHL1A2; PASNA; SANDD
UniProt ID: (Human) Q01668
Entrez Gene ID: (Human) 776
ion channel activity
voltage-gated calcium channel activity
calcium channel activity
protein binding
cytoskeletal protein binding
high voltage-gated calcium channel activity
ankyrin binding
metal ion binding
alpha-actinin binding
voltage-gated calcium channel activity involved in cardiac muscle cell action potential
voltage-gated calcium channel activity involved SA node cell action potential
ion transport
calcium ion transport
muscle contraction
cell communication
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
sensory perception of sound
regulation of metal ion transport
signaling
ion transmembrane transport
positive regulation of adenylate cyclase activity
neurological system process
positive regulation of transport
positive regulation of calcium ion transport
transmembrane transport
regulation of atrial cardiac muscle cell membrane repolarization
calcium ion import
calcium ion transmembrane transport
cardiac muscle cell action potential involved in contraction
membrane depolarization during cardiac muscle cell action potential
membrane depolarization during SA node cell action potential
regulation of heart rate by cardiac conduction
calcium ion import across plasma membrane
regulation of potassium ion transmembrane transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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