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Invitrogen
ZNF839 Polyclonal Antibody
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Product Details
PA5-54207
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human ZNF839. Recombinant protein control fragment (Product #RP-89017).
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: YKEFEELHKM VKKMCQDYLS SSGLCSQETL EINNDKVAES LGITEFLRKK EIHPDNLGPK HLSRDMDGEQ LEGASSEKRE REAAEEGLAS VKRPRREALS NDTTESLAAN SRGREKPRPL HALAAGTIVS QEEDI
Highest antigen sequence identity to the following orthologs: Mouse - 45%, Rat - 51%.
Target Information
ZNF839, also known as C14orf131, is an 811 amino acid protein that contains one C2H2-type zinc finger. The gene encoding ZNF839 localizes to chromosome 14 and, due to alternative splicing events, four ZNF839 isoforms are expressed. Chromosome 14 contains about 700 genes and 106 million base pairs and makes up about 3.5% of human cellular DNA. Chromosome 14 encodes the presinilin 1 (PSEN1) gene, which is one of the three key genes associated with the development of Alzheimer's disease. The SERPINA1 gene is located on chromosome 14 and when defective leads to the genetic disorder alpha1-antitrypsin deficiency. This disorder is characterized by severe lung complications and liver dysfunction. Notably, the immunoglobulin heavy chain locus is found on chromosome 14 and has been identified as a fusion with the chromosome 19 encoded protein BCL3 in the (14; 19) translocations found in a variety of B cell malignancies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Renal carcinoma antigen NY-REN-50; Zinc finger protein 839
Gene Aliases: C14orf131; ZNF839
UniProt ID: (Human) A8K0R7
Entrez Gene ID: (Human) 55778
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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