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Invitrogen
BAG3 Polyclonal Antibody
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Product Details
PA5-54239
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human BAG3. Recombinant protein control fragment (Product #RP-92058).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: DCSSSSSSAS LPSSGRSSLG SHQLPRGYIS IPVIHEQNVT RPAAQPSFHQ AQKTHYPAQQ GEYQTHQPVY HKIQGDDWEP RPLRAASPFR SSVQGASSRE GSPARSSTPL HSPSPIRVHT VVDRPQQPMT HRET
Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 91%.
Target Information
BAG3 are among BAG proteins that compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BAG family molecular chaperone regulator 3; BAG-3; Bcl-2 interacting cell death suppressor; Bcl-2-associated athanogene 3; Bcl-2-binding protein Bis; Bcl-2-binding protein BIS transcript 2; BCL2 associated athanogene 3; BCL2-binding athanogene 3; DKFZp434E0610; Docking protein CAIR-1; MGC104307; unnamed protein product
Gene Aliases: BAG-3; BAG3; BIS; CAIR-1; CMD1HH; CMT2JJ; HMND15; MFM6
UniProt ID: (Human) O95817
Entrez Gene ID: (Human) 9531
autophagosome assembly
protein folding
apoptotic process
extrinsic apoptotic signaling pathway via death domain receptors
striated muscle cell apoptotic process
negative regulation of striated muscle cell apoptotic process
spinal cord development
cellular response to heat
cellular response to unfolded protein
positive regulation of protein import into nucleus
negative regulation of apoptotic process
muscle cell cellular homeostasis
positive regulation of protein export from nucleus
protein stabilization
chaperone-mediated autophagy
aggresome assembly
cellular response to mechanical stimulus
extrinsic apoptotic signaling pathway
extrinsic apoptotic signaling pathway in absence of ligand
protein transport along microtubule
negative regulation of protein targeting to mitochondrion
positive regulation of aggrephagy
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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