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Invitrogen
UBR4 Polyclonal Antibody
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Product Details
PA5-54315
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human UBR4. Recombinant protein control fragment (Product #RP-90748).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: VEFGGNDLLQ VYNAQQIKHR LNSTGMYVAN TKPGGFTIEI SNNNSTMVMT GMRIQIGTQA IERAPSYIEI FGRTMQLNLS RSRWFDFPFT REEALQADKK LNLFIGASVD PAGVTMIDAV KIYGKTKEQF
Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 98%.
Target Information
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 600 kDa retinoblastoma protein-associated factor; E3 ubiquitin-protein ligase UBR4; N-recognin-4; p600; RBAF600; retinoblastoma-associated factor 600-like protein; retinoblastoma-associated factor 600; RBAF600; Retinoblastoma-associated factor of 600 kDa; RING-type E3 ubiquitin transferase UBR4; unnamed protein product; zinc finger UBR1-type protein 1
Gene Aliases: KIAA0462; KIAA1307; p600; RBAF600; UBR4; ZUBR1
UniProt ID: (Human) Q5T4S7
Entrez Gene ID: (Human) 23352
cytoplasmic translation
translational initiation
ubiquitin-dependent protein catabolic process
misfolded or incompletely synthesized protein catabolic process
fatty acid biosynthetic process
response to oxidative stress
endosome organization
proteasomal protein catabolic process
positive regulation of autophagy
protein ubiquitination
protein catabolic process
cellular response to stress
proteasome-mediated ubiquitin-dependent protein catabolic process
protein K27-linked ubiquitination
negative regulation of fatty acid biosynthetic process
protein stabilization
type I interferon signaling pathway
protein K48-linked ubiquitination
protein K11-linked ubiquitination
protein targeting to vacuole involved in autophagy
ubiquitin-dependent protein catabolic process via the N-end rule pathway
cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process
cytoplasm protein quality control
HRI-mediated signaling
negative regulation of HRI-mediated signaling
protein branched polyubiquitination
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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