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Invitrogen
KLHL26 Polyclonal Antibody
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Product Details
PA5-54688
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human KLHL26. Recombinant protein control fragment (Product #RP-93615).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LAVEYYVPET DQWTSVSPMR AGQSEAGCCL LERKIYIVGG YNWRLNNVTG IVQVYNTDTD EWERDLHFPE SF
Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 94%.
Target Information
KLHL26, part of the Kelch-like family member 26, is a protein-coding gene located on chromosome 19. It has been associated with various cellular functions due to its structural components, particularly the BTB/POZ domain at the N-terminus which spans about 115 amino acids. This domain plays crucial roles in forming E3 ubiquitin ligases by facilitating interactions with Cullin3 and enabling KLHL protein homodimerization. The significance of KLHL26 extends to its potential involvement in familial genetic conditions, as evidenced by the identification of a novel damaging variant, which was validated through Sanger sequencing in affected family members. Moreover, the Kelch motif within the KLHL proteins underlines their diverse roles in cellular morphology, gene expression regulation, and interaction with extracellular entities, including possible implications in actin binding and virus interactions post-infection.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: kelch-like 26; Kelch-like protein 26; unnamed protein product
Gene Aliases: KLHL26
UniProt ID: (Human) Q53HC5
Entrez Gene ID: (Human) 55295
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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