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Invitrogen
FAT1 Polyclonal Antibody
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Product Details
PA5-54910
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human FAT1. Recombinant protein control fragment (Product #RP-101000).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: NFQRALRNIL GVRRNDIQIV SLQSSEPHPH LDVLLFVEKP GSAQISTKQL LHKINSSVTD IEEIIGVRIL NVFQKLCAGL DCPWKFCDEK VSVDESVMST HSTARLSFVT PRHHRAAVCL CKEGRCP
Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 90%.
Target Information
This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and/or alternative promoter usage exist, but they have not been fully described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cadherin family member 7; cadherin ME5; cadherin-related family member 8; Cadherin-related tumor suppressor homolog; FAT tumor suppressor 1; Protein fat homolog; Protocadherin Fat 1
Gene Aliases: CDHF7; CDHR8; FAT; FAT1; hFat1; ME5
UniProt ID: (Human) Q14517
Entrez Gene ID: (Human) 2195
lens development in camera-type eye
epithelial cell morphogenesis
establishment of epithelial cell apical/basal polarity involved in camera-type eye morphogenesis
actin filament organization
cell adhesion
homophilic cell adhesion via plasma membrane adhesion molecules
establishment or maintenance of cell polarity
cell-cell signaling
anatomical structure morphogenesis
cell migration
camera-type eye development
cell-cell adhesion mediated by cadherin
establishment or maintenance of epithelial cell apical/basal polarity
camera-type eye morphogenesis
cell-cell adhesion
cellular response to angiotensin
positive regulation of vascular associated smooth muscle cell migration
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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