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Invitrogen
HESX1 Polyclonal Antibody
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Product Details
PA5-55007
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human HESX1. Recombinant protein control fragment (Product #RP-89385).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: QLGENKPSTC SFSIERILGL DQKKDCVPLM KPHRPWADTC SSSGKDGNLC LHVPNPPSGI SFPSVVDHPM PEERASKYEN YFSASERLSL KRELSWYRGR RPRTAFTQNQ IEVLENVFRV NCYPG
Highest antigen sequence identity to the following orthologs: Mouse - 77%, Rat - 79%.
Target Information
This gene encodes a conserved homeobox protein that is a transcriptional repressor in the developing forebrain and pituitary gland. Mutations in this gene are associated with septooptic dysplasia, HESX1-related growth hormone deficiency, and combined pituitary hormone deficiency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hAnf; Homeobox expressed in ES cells 1; Homeobox protein ANF; Rathke pouch homeobox; Rathke's pouch homeobox
Gene Aliases: ANF; CPHD5; HANF; HESX1; RPX
UniProt ID: (Human) Q9UBX0
Entrez Gene ID: (Human) 8820
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
protein binding
protein homodimerization activity
sequence-specific DNA binding
sequence-specific double-stranded DNA binding
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
brain development
gonad development
gene expression
Wnt signaling pathway
stem cell population maintenance
pituitary gland development
thyroid gland development
forebrain development
otic vesicle formation
multicellular organism growth
camera-type eye development
nose development
negative regulation of transcription, DNA-templated
regulation of embryonic development
forebrain morphogenesis
leukemia inhibitory factor signaling pathway
stem cell differentiation
canonical Wnt signaling pathway
ERK1 and ERK2 cascade
cellular response to cadmium ion
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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