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Invitrogen
Adenylate Cyclase 8 Polyclonal Antibody
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Product Details
PA5-55041
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human Adenylate Cyclase 8. Recombinant protein control fragment (Product #RP-93838).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: DRRNSGATFT EGSWSPELPF DNIVGKQNTL AALTRNSINL LPNHLAQALH VQSGPEEINK RIEHTIDLRS GDKLRREHIK PFSLMF
Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.
Target Information
Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. The enzymatic activity is under the control of several hormones, and different polypeptides participate in the transduction of the signal from the receptor to the catalytic moiety. Stimulatory or inhibitory receptors (Rs and Ri) interact with G proteins (Gs and Gi) that exhibit GTPase activity and they modulate the activity of the catalytic subunit of the adenylyl cyclase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AC8; adenylate cyclase 8 (brain); Adenylate cyclase type 8; Adenylate cyclase type VIII; Adenylyl cyclase 8; adenylyl cyclase-8, brain; ATP pyrophosphate-lyase 8; Ca(2+)/calmodulin-activated adenylyl cyclase; epididymis secretory sperm binding protein Li 172mP; HEL-S-172mP
Gene Aliases: AC8; ADCY3; ADCY8; HBAC1
UniProt ID: (Human) P40145
Entrez Gene ID: (Human) 114
nucleotide binding
actin binding
adenylate cyclase activity
calmodulin binding
ATP binding
calcium- and calmodulin-responsive adenylate cyclase activity
lyase activity
phosphorus-oxygen lyase activity
protein homodimerization activity
metal ion binding
protein heterodimerization activity
protein dimerization activity
protein phosphatase 2A binding
cAMP biosynthetic process
signal transduction
adenylate cyclase-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
learning or memory
memory
long-term memory
locomotory behavior
cyclic nucleotide biosynthetic process
glucose mediated signaling pathway
positive regulation of synaptic plasticity
positive regulation of insulin secretion
positive regulation of CREB transcription factor activity
activation of protein kinase A activity
intracellular signal transduction
positive regulation of insulin secretion involved in cellular response to glucose stimulus
opioid receptor signaling pathway
glucose homeostasis
regulation of insulin secretion
modulation of synaptic transmission
protein oligomerization
protein homooligomerization
regulation of cytosolic calcium ion concentration
cellular response to calcium ion
cellular response to morphine
cellular response to glucose stimulus
cellular response to glucagon stimulus
regulation of cellular response to stress
neuroinflammatory response
positive regulation of long-term synaptic potentiation
positive regulation of long term synaptic depression
cellular response to forskolin
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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