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Invitrogen
GZF1 Polyclonal Antibody
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Product Details
PA5-55099
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human GZF1. Recombinant protein control fragment (Product #RP-93594).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MLEVAEKLKC LDLSETCFQL KKQMLESVLL ELQNFSESQE VEVSSGSQVS AAPAPRASVA TDGPHPSGLT DSLDYPGERA SNGMSSDLPP KK
Highest antigen sequence identity to the following orthologs: Mouse - 73%, Rat - 73%.
Target Information
The GDNF-inducible zinc finger protein 1 (GZF1) is a sequence-specific transcriptional repressor with a BTB/POZ domain and ten zinc finger motifs whose expression is required for renal branching morphogenesis during kidney development. GZF1 binds to the 5'regulatory region of the homeodomain protein HOXA10, suggesting that GZF1 may play a role in morphogenesis other than kidney development. Recent experiments have indicated that GZF1 associates with nucleolin and this association is mediated by the first four zinc finger motifs of GZF1. It is thought that Nucleolin modulates the subcellular localization of GZF1 as well as its transcriptional repressor activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GDNF-inducible zinc finger protein 1; Zinc finger and BTB domain-containing protein 23; Zinc finger protein 336
Gene Aliases: GZF1; ZBTB23; ZNF336
UniProt ID: (Human) Q9H116
Entrez Gene ID: (Human) 64412
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding
sequence-specific DNA binding
metal ion binding
DNA-binding transcription factor
C2H2 zinc finger transcription factor
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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